Rejuran Bangkok: Polynucleotide Treatment for Acne Scars, Large Pores & Skin Regeneration

Achieving consistently smooth, youthful, and naturally luminous skin is a goal shared by individuals worldwide. However, the skin is continuously subjected to a barrage of extrinsic and intrinsic aging factors. Daily exposure to intense ultraviolet (UV) radiation, chronic environmental pollution, biological stress, and the natural decline of cellular function over time all contribute to structural breakdown. While high-end topical skincare products, oral vitamin supplements, and collagen drinks support general health, they frequently fall short of correcting deep dermal damage. This is because standard topical ingredients cannot effectively penetrate the epidermal barrier to alter cellular behavior within the true dermis.

The discovery of specialized Salmon DNA fragments capable of repairing and regenerating skin tissue at a fundamental, cellular level has fundamentally changed modern aesthetic medicine. This biostimulatory science forms the foundation of Rejuran Healer, an injectable treatment originating from South Korea that has quickly become a gold standard across Asia for skin rejuvenation.

For international patients, expatriates, and local residents seeking premium aesthetic care, BAC Clinic (Bangkok Aesthetics Clinic) in Bangkok, Thailand, offers customized, physician-led Rejuran treatments designed to target stubborn skin concerns at their root. This comprehensive, deep-dive guide explores the complex science, precise biological mechanisms, clinical combinations, and practical expectations surrounding Rejuran therapy.

1. The Core Science of Rejuran: Polynucleotides (PN) and Salmon DNA

To understand why Rejuran outperforms standard superficial skin treatments, it is essential to look at the underlying biochemistry of its primary active ingredient: Polynucleotide (PN).

What is a Polynucleotide?

Polynucleotides are specific biomolecules composed of long chains of nucleotide subunits linked together. Nucleotides are the fundamental building blocks of nucleic acids, which include Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA). The polynucleotide segments used in Rejuran are derived from the wild Pacific salmon (Oncorhynchus keta), specifically purified from salmon testes DNA.

Salmon DNA is selected for a highly precise biological reason: its base structure closely matches human DNA. Extensive biocompatibility testing has demonstrated that when this specific salmon DNA is purified and cleared of active proteins or antigenic cellular components, it is highly compatible with human physiology. When introduced into human skin tissue, it does not trigger a foreign body reaction, severe inflammation, or a systemic immune response. Instead, it functions as a natural bio-composite material that integrates into the extracellular matrix (ECM) to promote tissue self-renewal.

High Molecular Weight PN vs. PDRN

In aesthetic medicine, you will frequently encounter two terms derived from salmon DNA: PN (Polynucleotide) and PDRN (Polydeoxyribonucleotide). While they share a similar origin, they are distinct in their molecular weight, physical structure, and clinical indications.

• PDRN (Polydeoxyribonucleotide): PDRN consists of shorter, smaller, standardized fragments of DNA nucleotides. Because of its lower molecular weight and lower viscosity, PDRN is highly water-soluble and diffuses rapidly through tissue. It functions primarily as an accelerated healing agent. In clinical settings, PDRN is widely used to treat chronic wounds, diabetic ulcers, and acute tissue damage because it triggers rapid, short-term cellular repair. It is often referred to informally as a “salmon injection.”
• PN (Polynucleotide): PN, the active component in Rejuran, consists of much longer, higher molecular weight, intertwined double strands of nucleotides. Because the chains are longer, PN forms a cohesive, three-dimensional viscoelastic gel matrix when injected into the skin. This structure allows PN to remain stable within the dermis for an extended period. It provides immediate, physical scaffolding to support the extracellular matrix while continuously releasing nucleotide fragments that stimulate long-term structural remodeling, anti-aging benefits, and deep skin thickening.

2. Advanced Biological Mechanisms: How Rejuran Rejuvenates from Within

When Rejuran is introduced into the dermis via precise micro-injections, it triggers a cascade of intracellular and extracellular events that actively reverse tissue degeneration. It does not simply coat the cells or pull in water from the surrounding tissues; it actively alters the metabolic activity of the skin’s structural cells.

Fibroblast Proliferation and the A2 Purine Receptor

The primary cellular target of Rejuran is the fibroblast, the primary cell type in the dermis responsible for synthesizing collagen, elastin, and glycosaminoglycans (such as natural hyaluronic acid). As the skin ages or suffers damage from UV radiation, fibroblasts become dormant, flat, and less responsive, leading to skin thinning, wrinkles, and loss of structural elasticity.

Polynucleotide molecules act as direct ligands that bind to a specific surface protein on cells known as the A2 purine receptor (specifically the A2Areceptor subtype). The activation of this receptor pathway initiates an intracellular signaling cascade that achieves two key outcomes:

1. It signals dormant fibroblasts to enter the cell division cycle, significantly increasing the total number of active fibroblasts in the target area.
2. It upregulates the metabolic activity of these fibroblasts, forcing them to synthesize large amounts of Type I and Type III collagen, as well as native elastin fibers.

As a direct result of this biostimulatory action, the structural density and overall thickness of both the dermis and epidermis are measurably increased over a 4-week period.

Inflammation Control and Cytokine Regulation

Chronic low-grade inflammation, often accelerated by UV exposure and pollution, is a primary driver of skin aging, hyperpigmentation, and the breakdown of dermal structural integrity. Rejuran exerts a strong, documented anti-inflammatory effect by controlling the expression and secretion of signaling molecules called cytokines.

Upon injection, PN blocks the overproduction of pro-inflammatory cytokines (such as Interleukin-1, Interleukin-6, and Tumor Necrosis Factor-alpha) while simultaneously promoting the release of anti-inflammatory cytokines. This rebalancing of the dermal environment calms reactive skin conditions, reduces redness, mitigates post-inflammatory hyperpigmentation (PIH), and creates a stable environment that supports rapid tissue healing rather than tissue destruction.

Angiogenesis and Microcirculation Improvement

Healthy skin requires a robust microvascular network to supply oxygen and vital amino acids while removing metabolic waste products. Aging skin and scar tissue are often characterized by a reduction in capillary density, which leads to a dull, devitalized complexion and slower healing times.

Rejuran actively induces angiogenesis—the formation of new, healthy capillary blood vessels from existing vasculature. This process is driven by the localized stimulation and controlled secretion of Vascular Endothelial Growth Factor (VEGF). By rapidly improving microcirculation at the injection sites, Rejuran enhances nutrient delivery directly to the newly multiplied fibroblasts, providing them with the necessary raw materials to construct a fresh, resilient collagen matrix.

The Salvage Pathway: Energy-Efficient Repair

Every time a cell replicates or repairs its DNA, it requires a supply of purine and pyrimidine nucleotides. Cells can synthesize these nucleotides from scratch via the de novo pathway, a complex process that consumes significant cellular energy (ATP) and metabolic time.

Rejuran bypasses this energy drain by introducing a rich pool of pre-formed nucleotide fragments directly into the tissue. The cells absorb these fragments and utilize them through the Salvage Pathway. This metabolic pathway allows cells to recycle purines and pyrimidines directly into newly synthesized DNA and RNA. By providing an efficient, low-energy shortcut for cellular replication, the Salvage Pathway enables damaged, aged, or scarred skin tissue to regenerate and repair itself much faster than normal biological timelines allow.

3. Comprehensive Analysis: The 4 Authentic Korean Rejuran Formulas

To deliver targeted results for distinct clinical indications, PharmaResearch (the South Korean manufacturer of Rejuran) developed four specialized product formulations. Each formula features a customized molecular weight, viscosity, and concentration tailored to specific anatomical zones and skin pathologies.

At premier institutions like BAC Clinic, physicians carefully select the appropriate variant based on a detailed assessment of the patient’s skin depth, scar topography, and structural goals.

Product Comparison Matrix

Feature	Rejuran Healer (Classic)	Rejuran S (Scar)	Rejuran I (Eye)	Rejuran HB (Hydro Booster)
Packaging Color	Black Box	Blue Box	White Box	Red Box
Volume per Vial/Syringe	2.7 cc	1.0 cc	1.0 cc	1.0 cc
Viscosity & Elasticity	Moderate	High (Highly Concentrated Gel)	Low (Fluid & Thin)	Moderate-Low
Key Ingredients	Pure Polynucleotide (PN)	Pure Polynucleotide (PN)	Pure Polynucleotide (PN)	Polynucleotide (PN) + Non-Crosslinked HA + Lidocaine
Primary Target Layer	Superficial Dermis to Mid Dermis	Deep Dermis (Directly under scars)	Superficial Dermis / Periorbital	Superficial Dermis
Primary Indication	Full-face skin renewal, large pores, elasticity loss	Atrophic acne scars, deep indented scars, stretch marks	Dark under-eye circles, crow’s feet, thin periorbital skin	Severe skin dryness, early aging lines, low pain tolerance
Average Downtime (Bumps)	2 to 5 Days	1 to 3 Days (Localized)	1 to 2 Days	1 to 3 Days

Deep-Dive into Each Variant

Program Rejuran Healer (The Classic Black Box)

This is the flagship formulation containing 2.7 cc of pure, medium-viscosity polynucleotides per syringe. It is designed for generalized, full-face dermal administration. Rejuran Healer targets overall skin degradation by restoring global dermal thickness, balancing sebum production, shrinking enlarged pores, and creating a smooth, even texture across the cheeks, forehead, and jawline. It is the foundation of most cellular anti-aging protocols.

Program Rejuran S (The Blue Box)

Rejuran S is a highly concentrated, high-viscosity formulation packaged in a 1.0 cc syringe. Because of its elevated elastic modulus, it does not diffuse widely into surrounding tissues upon injection. Instead, it remains precisely where it is placed. This makes it ideal for treating atrophic acne scars (such as rolling, boxcar, and ice-pick scars). When injected directly beneath a depressed scar, it provides immediate structural lift while its high-density PN content drives intensive, localized tissue regeneration to permanently rebuild the missing dermal volume.

Program Rejuran I (The White Box)

The skin surrounding the human eye is exceptionally thin, delicate, and prone to early wrinkling, volume loss, and vascular shadowing (dark circles). Standard Rejuran Healer is too viscous for this area and can form small, persistent papules or lumps if injected superficially. Rejuran I is a low-viscosity, highly fluid formulation designed specifically for the periorbital region. It diffuses smoothly through the thin tissue under and around the eyes, thickening the skin barrier to hide underlying blood vessels (reducing dark circles) and softening fine lines without causing localized swelling.

Program Rejuran HB (The Red Box)

For individuals experiencing severe dermal dehydration alongside biological aging, Rejuran HB provides a dual-action approach. This formula combines high-molecular-weight Polynucleotide with non-crosslinked Hyaluronic Acid (HA). The non-crosslinked HA provides immediate, superficial hydration by drawing moisture into the upper skin layers, while the PN component works on long-term cellular repair. Furthermore, Rejuran HB contains 0.3% Lidocaine (a local anesthetic), which reduces the discomfort associated with dermal injections by up to 50%, making it an excellent option for patients with low pain tolerance.

Powerful Synergistic Effect
in Rejuvenation and Hydration!

4. Program Rejuran vs. The Field: Head-to-Head Aesthetic Comparisons

When evaluating skin rejuvenation options in Bangkok, patients are frequently presented with a wide array of terms: Skin Boosters, Dermal Fillers, and Poly-L-Lactic Acid (PLLA) Biostimulators. To make an informed decision, it is vital to understand how Rejuran compares to these alternative modalities in terms of composition, mechanism, and clinical results.

Comprehensive Treatment Modality Matrix

Treatment Category	Rejuran Healer (PN)	Traditional Skin Boosters (HA)	Crosslinked Dermal Fillers	Collagen Biostimulators (PLLA/CaHA)
Primary Ingredient	Polynucleotide (PN) from Salmon DNA	Non-Crosslinked Hyaluronic Acid	Crosslinked Hyaluronic Acid (HA)	Poly-L-Lactic Acid (Sculptra) / Calcium Hydroxyapatite
Mechanism of Action	Cellular Bio-regeneration: Stimulates fibroblast multiplication via purine receptors; repairs DNA.	Passive Hydration: Hydrophilic molecules bind water to temporarily increase skin moisture.	Mechanical Volumization: Cohesive gel physically lifts tissue to fill structural deficits.	Controlled Inflammatory Stimulation: Microparticles trigger a localized foreign-body response to produce collagen.
Volumizing Capability	Low (Focuses on skin thickness, not contour shaping).	None (Increases plumpness via water retention only).	High (Reshapes cheekbones, chin, lips, and deep folds).	High-Moderate (Gradually restores large-scale volume loss).
Effect on Acne Scars	Excellent for repairing tissue structure at the cellular level.	Poor (Temporary softening via localized hydration only).	Good for immediate lifting, but does not repair underlying tissue.	Excellent for filling large areas of volume loss, but less precise for individual scars.
Longevity of Results	6 to 12 Months (Following a full initial induction series).	1 to 3 Months (Requires frequent redos due to rapid degradation).	6 to 24 Months (Depending on the crosslinking technology used).	18 to 24 Months (Due to gradual, progressive collagen production).
Target Skin Layer	Superficial to Mid Dermis	Epidermis to Superficial Dermis	Deep Dermis, Subcutaneous, or Supraperiosteal	Deep Subcutaneous or Periosteal Layers

Detailed Comparative Analysis

Rejuran vs. Traditional Non-Crosslinked Skin Boosters

Traditional skin boosters (such as classic, uncrosslinked hyaluronic acid micro-injections) function purely as localized humectants. Hyaluronic acid molecules possess an extraordinary capacity to bind water molecules, instantly plumping the skin and imparting a temporary dewy sheen. However, uncrosslinked HA is rapidly broken down by the body’s endogenous hyaluronidase enzymes within a few weeks. It does not alter cellular health, thicken the genetic structure of the skin, or repair scarred tissue.

Rejuran, conversely, is not a simple hydrator. It represents structural medicine. While it provides mild initial hydration, its primary value lies in its ability to permanently increase cellular density and rebuild a compromised skin barrier. When the two are combined, they produce a powerful synergistic effect: the HA creates an optimal fluid environment that supports the rapid migration and proliferation of the fibroblasts stimulated by Rejuran.

Rejuran vs. Crosslinked HA Dermal Fillers

Crosslinked dermal fillers are engineered using chemical binders (such as BDDE) to link hyaluronic acid chains together, creating a firm, cohesive, and long-lasting gel. These products are placed deep within the facial tissues to act as structural implants, filling hollow temples, lifting sagging cheeks, or defining the jawline. Fillers are passive; they do not repair cells or change skin quality—they simply alter facial contours through mechanical volumization.

Rejuran lacks this heavy structural lifting capability and cannot reshape facial contours. However, it can be safely injected into the superficial dermis across the entire face—an area where thick dermal fillers cannot be placed without causing severe contour irregularities, lumps, or vascular occlusion. Dermal fillers address structural hollowing, while Rejuran addresses the health and texture of the skin sheet covering that structure.

Rejuran vs. PLLA/CaHA Collagen Biostimulators

Advanced biostimulators like Poly-L-Lactic Acid (Sculptra) or Calcium Hydroxyapatite (Radiesse) work through a mechanism known as controlled sub-clinical inflammation. When injected into the deep subcutaneous layers, these microparticles trigger a mild, localized foreign-body response. The immune system reacts by surrounding these particles with fresh networks of Type I collagen. These treatments are highly effective for correcting structural volume loss across large areas, such as gaunt cheeks or a hollow pre-auricular zone, in older individuals.

Rejuran achieves its biostimulatory effects via a non-inflammatory pathway. It directly engages the cell’s purine receptors and utilizes the Salvage Pathway to encourage natural growth, avoiding the use of an inflammatory tissue reaction. This allows Rejuran to be used safely in highly superficial layers, including the delicate skin under the eyes, across active acne zones, and on hyper-reactive or thin skin where inflammatory biostimulators cannot be administered.

5. Clinical Synergy: Combining Rejuran with High-Tech Energy-Based Devices (EBD)

In modern aesthetic medicine, relying on a single treatment modality can sometimes limit the speed and depth of structural improvement. At premier institutions like BAC Clinic, physicians frequently design combined protocols that pair Rejuran injections with advanced energy-based devices. This approach pairs the physical tissue remodeling of lasers with the biochemical cellular repair of polynucleotides.

The Picosecond Laser + Rejuran Protocol

Picosecond lasers deliver ultra-short bursts of laser energy (measured in trillionths of a second) into the skin tissue. When utilized with a specialized fractional or honeycomb focusing lens, the laser creates a phenomenon known as Laser-Induced Optical Breakdown (LIOB) within the dermis. This process creates tiny, localized cavities or micro-vacuoles beneath the skin surface without damaging the outermost epidermal layer. These micro-injuries signal the body to begin a rapid healing response.

When Rejuran is injected immediately following a Picosecond Laser session, the clinical outcomes are significantly enhanced:

1. Accelerated Recovery: The anti-inflammatory and tissue-regenerating properties of the PN molecules quickly calm the heat and redness induced by the laser, reducing typical post-laser downtime from several days to under 48 hours.
2. Synergistic Collagen Synthesis: The laser provides a powerful physical stimulus for tissue remodeling, while Rejuran provides the essential chemical building blocks (via the Salvage Pathway) and activates fibroblasts. Together, they achieve a faster reduction in atrophic acne scars and a more pronounced reduction in pore size than either treatment could produce alone.
3. Advanced Pigmentation Cleansing: Picosecond energy mechanically shatters stubborn melanin clusters (melasma, sun spots, freckles) into microscopic particles that are easily cleared by the lymphatic system. Concurrently, Rejuran works at a genetic level to downregulate the expression of genes responsible for melanogenesis (pigment production), helping to prevent rebound hyperpigmentation and leading to a more stable, even skin tone.

The INFINI Microneedle Fractional RF (MFR) + Rejuran Protocol

The INFINI MFR system utilizes a grid of insulated gold-coated microneedles to physically penetrate the epidermis and deliver precisely metered radiofrequency (RF) energy directly into the deep layers of the dermis. This thermal energy causes immediate tightening of the existing collagen fibers and creates controlled zones of electro-coagulation, forcing the deep dermis to naturally tighten and lift.

Injecting Rejuran in tandem with an INFINI RF treatment yields exceptional clinical benefits for skin tightening and deep scar correction:

• The mechanical microneedling channels provide a direct pathway for the superficial distribution of Rejuran, ensuring uniform dermal absorption.
• The heat generated by the RF device activates localized cell signaling pathways. When met with the purine receptor stimulation of the PN molecules, it triggers a major increase in fibroblast multiplication.
• This combination is highly effective for smoothing deep, fibrous acne scars and restoring structural elasticity to loose, sagging skin along the lower face and jawline.

6. The Precise Clinical Procedure: What Happens at BAC Clinic

Receiving a Rejuran treatment at a highly regarded establishment like BAC Clinic involves a structured, multi-step clinical process designed to maximize product efficacy, ensure absolute patient safety, and maintain a high level of comfort.

Step 1: Skin Assessment and Consultation

The process begins with a formal clinical consultation. The physician evaluates the patient’s face to assess skin thickness, laxity, pore diameter, and scar depth. The doctor confirms that the patient is a suitable candidate, rules out any localized contraindications (such as active facial infections or open wounds), and selects the ideal Rejuran formulation (or combination approach) required to meet the patient’s structural goals.

Step 2: Advanced Topical Anesthesia

The target areas are thoroughly cleansed using a medical-grade anti-bacterial solution to remove all sebum, makeup, and surface debris. Next, a premium, high-strength topical numbing cream (typically containing an optimized lidocaine blend) is applied evenly across the face. The area is occluded with a clear medical wrap to enhance skin penetration. The numbing cream is left to take full effect for approximately 30 to 45 minutes, ensuring that the subsequent injection process is virtually painless.

Step 3: Precise Manual Injection Technique

Once the skin is fully desensitized, the numbing cream is removed, and the face is prepped again with an antiseptic solution (such as chlorhexidine). The physician then performs the treatment using a manual micro-injection technique.

Using a highly specialized ultra-fine aesthetic needle (typically a 33G needle measuring just 4mm in length), the doctor administers micro-droplets of Rejuran into the Superficial Dermis and Intradermal layers of the skin.

• Each injection point receives a precise dose of 0.05 to 0.1 milliliters of the PN solution.
• The injection points are spaced evenly in a grid pattern, roughly 0.5 to 1.0 centimeter apart across the treatment zone.
• Special attention is paid to specific problem areas, such as directly beneath rolling acne scars, around large pores on the nose and inner cheeks, or within fine lines on the forehead.

Why Manual Injection is Best: Automated Meso Guns use a mechanical vacuum to hold the skin while multi-needle cartridges quickly fire the product. While fast, Meso Guns often suffer from product leakage, where expensive Rejuran spills onto the skin surface rather than penetrating the tissue. Furthermore, mechanical guns use fixed pressure that can push the product too deep into the subcutaneous fat layer, missing the true dermis where fibroblasts reside. Manual injection allows the physician to adjust the angle, depth, and volume at every single point, ensuring the entire dose is delivered precisely into the target layer for optimal clinical results.

Step 4: Post-Treatment Cold Therapy and Photobiomodulation

Immediately following the micro-injections, small, raised papules or bumps will be visible at each injection site, resembling small mosquito bites. This is a normal response indicating that the viscoelastic PN gel has been correctly placed within the upper dermis.

To soothe the skin, a cooling gel or specialized medical mask is applied. This is followed by Red Light Therapy (Photobiomodulation) using a specific wavelength (typically around 633 nanometers) for 15 to 20 minutes. The red light energy penetrates deep into the tissues to reduce localized swelling, accelerate the resolution of needle marks, and work synergistically with Rejuran to stimulate early collagen production.

7. What to Expect: Timelines, Downtime, and the Induction Protocol

Understanding the timeline of a biostimulatory treatment like Rejuran is critical to managing clinical expectations. Because Rejuran works by stimulating natural cellular growth rather than using synthetic artificial fillers, the transformation happens gradually as the skin structures rebuild.

Biological Evolution Timeline

Time elapsed	Internal Biological Activity	Visible External Skin Changes
Days 1 to 3	PN gel integrates into the extracellular matrix; anti-inflammatory cytokines clear localized injection swelling.	Micro-bumps at injection sites flatten; skin redness and needle marks fade.
Weeks 1 to 2	Fibroblasts begin multiplying via purine receptor activation; early synthesis of native hyaluronic acid commences.	Skin hydration improves; sebum production balances, reducing surface oiliness; complexion looks brighter.
Weeks 3 to 4	Advanced neo-collagenesis occurs; Type I and III collagen fibers thicken; epidermis increases in overall structural density.	Skin elasticity rises; pores tighten; fine lines soften; atrophic acne scars begin to appear shallower.
Months 2 to 6	Continuous structural remodeling of the dermis; long-term reinforcement of the skin’s protective barrier.	Cumulative structural improvement; skin appears denser, firmer, and smoother, showing a distinct healthy glow.

The Clinical Induction Protocol

A single session of Rejuran will provide early hydration and mild balancing benefits, but it is insufficient to achieve long-term cellular regeneration or structural remodeling. To build a solid foundation of fresh collagen and achieve significant, lasting skin thickening, patients should follow a structured initial protocol:

• The Loading Phase: A complete course consists of 3 to 4 consecutive sessions spaced precisely 2 to 4 weeks apart. This frequency keeps the dermal fibroblasts continuously active, allowing the cumulative effect of the polynucleotides to fully restructure the tissue.
• The Maintenance Phase: Because the human body continuously ages and undergoes environmental exposure, the newly formed collagen will slowly break down over time. To maintain the structural improvements, a single maintenance treatment is recommended every 3 to 6 months (or 6 to 12 months for younger skin types).

8. Clinical Safety: Contraindications, Side Effects, and Post-Care

Rejuran maintains an excellent safety record due to the natural biocompatibility of purified salmon DNA. However, as an injectable medical procedure, certain safety guidelines, contraindications, and post-treatment care instructions must be carefully followed.

Absolute and Relative Contraindications

Rejuran should not be administered to individuals who fall under any of the following categories:

1. Severe Seafood Allergies: While the purification process removes most cellular proteins, individuals with a documented history of severe anaphylactic reactions to fish or seafood should avoid Rejuran as a precautionary measure.
2. Active Skin Infections: Treatments cannot be performed if there is an active bacterial, viral, or fungal infection (such as a herpes simplex cold sore outbreak, active cystic acne breakouts, or impetigo) in the target injection zone.
3. Blood Disorders and Anticoagulant Use: Patients with bleeding disorders or those taking high doses of blood-thinning medications (such as Warfarin, Aspirin, or high-dose NSAIDs) may experience increased bruising and should consult their physician before treatment.
4. Keloidal Tendency: Individuals prone to developing severe keloids or hypertrophic scars from minor needle punctures require careful medical evaluation before proceeding.

Expected Post-Procedure Side Effects

The side effects associated with Rejuran are localized, temporary, and directly related to the physical injection process rather than the product itself:

• Intradermal Papules (Bumps): The small, raised bumps at the injection sites are completely normal and expected. They typically resolve within 1 to 3 days on the face as the high-molecular-weight PN gel absorbs into the surrounding dermis. In rare cases or in areas with very thin skin (like under the eyes), they can take up to 5 days to fully smooth out.
• Erythema and Mild Swelling: General skin redness and mild swelling caused by the needle punctures will typically subside within 24 to 48 hours, accelerated by post-treatment red light therapy.
• Petechiae or Bruising: Tiny pin-prick bruises may occasionally occur, especially in vascular areas around the eyes or lower cheeks. These safely fade over 3 to 7 days and can be easily covered with light makeup once the injection points close.

Essential Post-Treatment Care Instructions

To safeguard your results and minimize recovery time, follow these post-care steps:

1.Do Not Wash the Face:First 6 Hours

Keep the treated skin completely dry and untouched for at least 6 hours following the injections. This allows the microscopic needle entry points to close completely, preventing environmental bacteria from entering the dermis.

2.Gentle Cleansing and Intensive Hydration:Days 1 to 7

Wash the skin using only a mild, non-soap cleanser and lukewarm water. Because the skin may feel temporarily dry for 1 to 2 weeks while collagen synthesis accelerates, apply generous amounts of a pure, fragrance-free moisturizer and a soothing hyaluronic acid serum.

3.Apply Broad-Spectrum Sun Protection:Ongoing

Protect the regenerating skin cells from UV damage by applying a broad-spectrum sunscreen with an SPF rating of 50 or higher daily. Avoid direct, prolonged sun exposure for at least 1 week post-procedure.

4.Avoid Extreme Heat and Intense Exercise:First 48 Hours

Stay away from hot saunas, steam rooms, public swimming pools, hot tubs, and vigorous physical workouts for 48 hours. Excessive sweating and heat can worsen localized swelling and increase the risk of bruising or secondary infection.

5.Refrain from Harsh Skincare Actives:First 5 Days

Do not apply topical products containing strong active ingredients, such as Retinol, Retin-A, Glycolic Acid (AHA), Salicylic Acid (BHA), or high-dose Vitamin C serums. Allow the skin’s barrier to strengthen before reintroducing exfoliating agents.

9. Exhaustive Frequently Asked Questions (FAQ)

Is Rejuran treatment painful?

Because the procedure involves multiple micro-injections across the face, mild discomfort is expected. However, it is highly manageable. At BAC Clinic, we apply a high-strength topical numbing cream for 30 to 45 minutes prior to the procedure, which deeply desensitizes the skin. Most patients describe the sensation as a minor, localized pinching or stinging. For individuals with low pain tolerance, Rejuran HB is an excellent alternative, as it contains built-in Lidocaine to reduce discomfort during delivery.

How soon will I see visible results after my first Rejuran injection?

Rejuran is a biostimulator that relies on natural cell growth, so its effects appear gradually. During the first 1 to 2 weeks, you will notice an initial improvement in skin hydration, a more balanced oil-to-moisture ratio, and a smoother texture. The true structural changes—such as increased skin elasticity, tighter pores, and the softening of acne scars—become more visible between weeks 3 and 4 as the fresh collagen networks mature. The most significant and transformative results build up progressively after your 3rd or 4th session.

Can Rejuran completely eliminate deep acne scars?

Rejuran S significantly improves atrophic acne scars by stimulating the permanent generation of fresh dermal tissue directly beneath the depressions. While it can dramatically reduce scar depth and smooth out uneven skin texture, very deep, fibrotic scars (such as severe ice-pick or anchored boxcar scars) may require a combination approach. For these cases, pairing Rejuran with subcision (physically releasing the fibrous bands under the scar) or Picosecond Laser / Fractional RF yields the most comprehensive, smooth results.

Is there a risk of developing permanent lumps or nodules from Rejuran?

No. Unlike dermal fillers or synthetic permanent implants, Rejuran consists of natural, completely biodegradable polynucleotide chains. It does not contain crosslinked starches or synthetic polymers. Once it triggers fibroblast replication and completes its biostimulatory cycle, the PN fragments are safely broken down and cleared by the body’s normal metabolic processes. The temporary micro-papules that form immediately after injection are simply pockets of the fluid gel that naturally dissolve into the dermis within 1 to 3 days.

Can I receive Rejuran if I have active acne breakouts?

Yes, Rejuran is highly beneficial for acne-prone skin. Its anti-inflammatory properties help calm active inflammatory acne lesions and reduce the redness associated with breakouts. By regulating sebum production and restoring a balanced oil-water environment, it helps minimize future pore cloggings. Furthermore, injecting Rejuran during the early stages of acne recovery accelerates wound healing, significantly reducing the likelihood that active acne lesions will develop into permanent atrophic scars.

Can Rejuran be injected into the lips?

Rejuran Healer can be injected superficially around the border of the lips to smooth fine vertical perioral lines (smoker’s lines) and improve thin skin density. However, because Rejuran is a skin regenerator and not a mechanical dermal filler, it will not add structural volume, fullness, or shape contours to the lips or nose.

Can pregnant or breastfeeding women undergo Rejuran treatments?

While purified salmon DNA is biocompatible and non-toxic, clinical safety studies on the use of polynucleotide injectables in pregnant or lactating women are limited. As a standard medical precaution, aesthetic treatments involving injectables are generally not recommended during pregnancy or breastfeeding. It is best to postpone your Rejuran sessions until after pregnancy and completion of the breastfeeding phase.

What is the difference between Rejuran and Exosome treatments?

Both represent advanced developments in regenerative medicine, but they contain different biological components. Rejuran provides pure Polynucleotide (PN) chains that serve as structural building blocks and directly activate the cell’s purine receptors. Exosomes are microscopic extracellular vesicles harvested from stem cells that contain a complex mix of growth factors, signaling proteins, and microRNA. Exosomes act as direct messengers that tell cells how to behave. In many advanced skin protocols, they are used together: Exosomes are applied superficially following microneedling or laser treatments to maximize cellular communication, while Rejuran is injected into the deeper dermis to provide structural scaffolding and drive long-term collagen synthesis.

How long do the effects of a full Rejuran series last?

After completing an initial loading protocol of 3 to 4 sessions, the structural improvements, increased skin thickness, and collagen density typically remain stable for 6 to 12 months. The longevity of your results depends on your age, lifestyle factors (such as sun exposure, smoking, and sleep habits), and your skin’s natural aging rate. Undergoing a single maintenance treatment every 3 to 6 months helps keep fibroblasts active, allowing you to maintain a youthful, glowing complexion indefinitely.

10. Conclusion and Contact Information

Rejuran Polynucleotide therapy represents a significant advancement in modern anti-aging medicine by moving away from temporary cosmetic concealment and focusing on actual structural repair at a cellular level. By utilizing the biocompatible properties of purified salmon DNA, Rejuran activates dormant fibroblasts, controls chronic tissue inflammation, improves microcirculation, and leverages the highly efficient Salvage Pathway to naturally thicken and rebuild the skin matrix from within.

Whether you are seeking to repair deep atrophic acne scars, shrink persistent large pores, smooth fine lines, or achieve a healthy, luminous glow, selecting the right clinic and injection technique is critical to your success.

At BAC Clinic (Bangkok Aesthetics Clinic), located in the heart of Bangkok, Thailand, we prioritize patient safety, absolute product authenticity, and precise medical care. Our experienced physicians utilize a meticulous manual injection technique to ensure that every micro-droplet of genuine Rejuran is placed exactly within the true dermal layer for optimal cell activation. Furthermore, our customized combination protocols—pairing Rejuran with state-of-the-art Picosecond Lasers or INFINI Fractional RF devices—are designed to deliver faster, more comprehensive results for complex skin concerns.

Take the first step toward true skin health and cellular regeneration by scheduling a private consultation with our medical team today.

Schedule Your Appointment at BAC (Bangkok Aesthetics Clinic)

• 🏢 Official Clinic Name: Bangkok Aesthetics Clinic (BAC Clinic)
• Clinic License Number: 10101010961
• 🗺️ Map & Driving Directions: https://maps.app.goo.gl/kKE6w4nj5xS1ZHaX7
• 📍 Physical Address: BAC Clinic, 180 Sixteenth Place, 1st Floor, Sukhumvit Soi 16, Khlong Toei, Bangkok 10110, Thailand. (Centrally located in the Sukhumvit district, easily accessible by public transit systems with dedicated parking available on-site).
• 📞 Telephone Hotline: +66 2 0033365
• 📧 Official Email: baclasercenter@gmail.com
• 🟢 Line Official ID Account: @bacclinic (Direct Link: https://lin.ee/v14tokW
• 📸 Instagram Profile: BAC_CLINIC
• 🔵 Facebook Platform: BAC Clinic (bangkokaestheticsclinic)

Clinical Operating Hours

• Tuesday through Friday: 11:00 AM to 8:00 PM
• Saturday and Sunday: 11:00 AM to 7:00 PM
• Mondays: Closed For Weekly Maintenance

Unlock your skin’s natural healing potential and discover a refreshed, structurally youthful version of yourself with the guidance of the medical experts at BAC Clinic